By Alex Avdeef
Explains tips to practice and study the result of the newest physicochemical methods
With this booklet as their consultant, readers have entry to all of the present details had to completely examine and safely be sure a compound's pharmaceutical houses and their results on drug absorption. The publication emphasizes oral absorption, explaining the entire physicochemical equipment used at the present time to investigate drug applicants. in addition, the writer offers professional counsel to assist readers learn the result of their reviews so that it will decide on the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating the entire most recent learn findings, equipment, and assets, including:
Descriptions and purposes of latest PAMPA versions, drawing on greater than thirty papers released through the author's study group
Two new chapters interpreting permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded details and techniques to help pKa determination
New examples explaining the remedy of virtually insoluble try compounds
Additional case stories demonstrating using the most recent physicochemical techniques
New, revised, and multiplied database tables during the book
Well over two hundred drawings support readers greater comprehend tricky recommendations and supply a visible consultant to complicated tactics. furthermore, over 800 references function a gateway to the first literature within the box, facilitating additional examine into the entire themes coated within the book.
This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable components of study. it's also suggested as a supplemental textual content for graduate classes in pharmaceutics.
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Additional resources for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef